Heterochromatin Protein 1

  • OMIM: 604 511
  • MGI: 105369

In the family of heterochromatin proteins 1 ( HP1 ) (also " Chromobox homologue ", CBX ) is highly conserved adapter molecules that play a variety of essential functions in the nucleus. These include the epigenetic gene regulation, maintenance of genome stability and the formation of a "platform" for the reconstruction of cell nuclei in the final stages of mitosis. First described it in 1986 by Sarah Elgin in Drosophila melanogaster as a protein, which is connected as a mutant form with suppression of position effect variegation. 1991 was detected by Prim Singh that HP1 is a highly conserved protein of heterochromatin and plays a fundamental role in the epigenetic regulation.

Isoforms

In mammals, there are isoforms HP1α, HP1β and HP1γ.

HP1β

HP1β interacts directly with the histone methyltransferase Suv ( 3) 9h1 and is a component of pericentric heterochromatin and telomeric. HP1β can shut down dose - dependent genes in pericentric heterochromatin. The process of closing down is mediated by the interaction of the HP1β chromodomain and histone - Me ( 3) K9H3.

Protein isoform Human Genome Organisation Mouse Genome Informatics Entrez Ensembl UniProt National Center for Biotechnology Information Epigenetics PubMed Central Digital Object Identifier Nature Genetics
170750
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