Inositol trisphosphate

  • Inositol -1 ,4,5- trisphosphate
  • IP3
  • InsP3

White powder

Fixed

Template: Infobox chemical / molecular formula search available

Inositol trisphosphate (also inositol -1 ,4,5- trisphosphate, IP3 short ) referred to in the biochemistry of a phospholipid a vacant compound as a second messenger for signal transduction ( signal transduction) in the cell is important.

Biosynthesis and other reactions

By activation of a G -protein coupled receptor or a membrane-bound tyrosine kinase which stimulates phospholipase C. This cleaves the membrane lipid phosphatidylinositol -4 ,5 -bisphosphate ( PIP2 ) to diacylglycerol (DAG ) and inositol trisphosphate.

Inositol trisphosphate is disabled in cell metabolism through the IP3 - phosphatase Inositolbissphosphat. A further phosphorylation by the IP3 -3- kinase ( EC 2.7.1.127, three isoforms: A, B and C) at the 3-position leads a chain reaction towards another, higher phosphorylated inositol phosphates one, also fulfill the functions in the regulation of cell could.

CAS registry number PubChem Phosphatidylinositol 3,4-bisphosphate Inositol trisphosphate receptor Cytosol Smooth muscle tissue Proteinkinase C Calmodulin
413256
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