Lipohyalinosis

Lipohyalinosis is a pathological process in vessel walls of small perforating arteries and arterioles of the brain. The term is used synonymously with " fibrinoid necrosis ". Fibrinoid necrosis is caused by the entry of plasma proteins in the vessel wall and is more frequent in subjects with hypertension than in those with normal blood pressure. It can lead to occlusion of the affected vessel and cause a lacunar infarct. The term " lipohyalinosis " was coined by Charles Miller Fisher, the term " fibrinoid necrosis " but describes the underlying pathological changes in more detail.

Swell

  • Fisher CM (1971 ) Pathological observations in hypertensive cerebral hemorrhage. In: J Neuropathol Exp Neurol, 30:536-550. PMID 4105427 ( doi: 10.1097/00005072-197107000-00015, and only for subscribers. )
  • Rosenblum WI. Fibrinoid necrosis of small brain arteries and arterioles and military aneurysms as Causes of hypertensive hemorrhage: a critical reappraisal. In: Acta Neuropathol, 2008 July 19 PMID 18,642,006
  • Pathology
  • Angiology
Artery Digital Object Identifier Acta Neuropathologica
514955
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