Lovastatin

  • Mevinolin
  • Monacolin -K
  • MK -803
  • [( 1S, ​​3R, 7S, 8S, 8aR ) - 8 - [2 - [( 2R, 4R )-4- hydroxy-6- oxooxan -2-yl ] ethyl] - 3,7- dimethyl-1, 2, 3,7,8,8 a- hexahydro -naphthalene -1-yl ] (2S )-2- methylbutanoate

C10AA02

Colorless crystals

Statins

HMG-CoA reductase inhibitor

174.5 ° C

  • Insoluble in water (2.14 mg · l-1 at 25 ° C)
  • Slightly soluble in ethanol, insoluble in acetone and chloroform

Attention

> 1000 mg · kg -1 ( LD50, mouse, oral)

Template: Infobox chemical / molecular formula search available

Lovastatin is the generic name of a drug selected from the group of statins, used in the treatment of hypercholesterolemia. It was the first statin used in the lipid-lowering and was admitted as Mevacor in 1987 by the FDA for the U.S. market in 1989 was admitted in Germany.

Lovastatin belongs to the naturally occurring Monaco Linen and from the fungus Aspergillus terreus, and also by certain higher fungi such as Pleurotus ostreatus ( oyster mushroom ) and the closely related Pleurotus spp. produced.

Its action as a lipid-lowering agent, such as based on all statins on the inhibition of HMG- CoA reductase.

It was one of the statins, with the MSD Sharp & Dohme 1980, the first ( animal experiment ) studies began. However, Sankyo, a study with the almost same structure mevastatin for a heaping occurrence of side effects broke, Merck abruptly ended the studies.

Production

For use as a drug lovastatin is produced in a multistage fermentation process of Aspergillus terreus and Monascus ruber, is described in addition, the total synthesis.

CAS registry number PubChem Anatomical Therapeutic Chemical Classification System DrugBank Dangerous Substances Directive (67/548/EEC) Active ingredient
531089
de