Mark Edusei began his career at King Faisal Babes and changed in the season 1996 /97 on the Italian second division side U.S. Lecce here he remained until the 1999/00 season when he União Leiria to in the Portuguese Super Liga. After a year in Portugal, he moved to AC Bellinzona in the Challenge League. For the 2001/02 season Edusei returned to Italy to Cosenza Calcio. After two seasons at Sampdoria, he moved to league rivals Piacenza Calcio. For the season 2004 /05 Edusei moved to Sampdoria in the Serie A. Shortly after the beginning of the season 2005/ 06 changed the Ghanaians to Torino where he immediately became a regular player. For the 2006/07 season, he joined the newly promoted Catania Calcio.
In the Ghanaian national Edusei played so far five times.