Na-K-Cl cotransporter

  • OMIM: 600 840
  • UniProt: P55011

Na - K- 2Cl cotransporter is a protein which is the absorption of sodium, potassium and chloride. It is an electromagnetically neutral transport protein, as well as two negative ions move along with two positive ions into the cell.

Properties

There are two subtypes, and NKCC1 NKCC2:

  • NKCC1 can occur in all cells of the body, but especially in excretory ducts of glands and only during embryogenesis. Thus, the effect of the neuronal response to γ -aminobutyric acid ( GABA) and glycine changes from activating to inhibitory.
  • NKCC2, however, is limited to the kidney. It is used in the ascending limb of Henle's loop to the sodium rückzuresorbieren and to concentrate the urine. The case recorded potassium can get back into the lumen via the ROMK1 channel again. The leaves as well as the sodium chloride the basolateral cell. In the thick ascending limb of Henle's loop saline is reabsorbed without water may be followed, as this part of the loop is impermeable to water. This now leads to more water limb of Henle's loop passes from the thin descending into the interstitial space and the urine is thus concentrated.

Pathophysiology

A fault in the loop of Henle in NKCC2 it comes to so called Bartter 's syndrome, which is characterized by hypotension.

Inhibitors

An inhibitor of this transporter is furosemide, a diuretic. It is one of the loop diuretics. Because now no more sodium is reabsorbed, among other things, from fall of blood pressure.

Human Genome Organisation Chlorine Transportprotein Stroma (animal tissue) Bartter syndrome Digital Object Identifier
589933
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