Natta projection

The wedge bar formula ( engl. Natta projection after Giulio Natta ) belongs to the chemical structural formulas. It shows the spatial arrangement of the molecular constituents ( the substituent). This communication and knowledge of the spatial arrangement is particularly the case of chiral drugs of considerable practical importance, since the stereoisomers usually develop different pharmacological effects in the body.

Useful is the use of the wedge bar formula, also wedge bar notation, especially to illustrate the stereochemistry of a molecule, such as, the absolute configuration can also be recognized in the two-dimensional plane of the drawing. A filled wedge in this case indicates that the radical (or substituent or atom ) protrudes from the plane of the drawing, a dotted wedge or a dotted line indicates that the substituent is behind the plane of the drawing. Bonds that lie in the plane drawn as simple lines. When methane ( bond angle H -C -H: 109 ° 28 ') are, for example,

  • Two carbon-hydrogen bonds in the plane of the drawing ( single line )
  • A carbon -hydrogen bond projects from the drawing plane ( wedge-shaped fat- subscribed bond) and
  • A carbon -hydrogen bond is located behind the plane ( dashed bond).

The dashed-wedged line presentation is seldom addressed, but usually combined with a skeletal formula used.

Active ingredient Lewis structure Molecular configuration Haworth projection European Journal of Clinical Pharmacology Digital Object Identifier
470680
de