Neurodegeneration

As neurodegenerative diseases ( Greek νέυρο, neuro, " nerve [ s ] - " and Latin dēgenerāre, " from " or " degenerate " ) is defined as a group of mostly slowly progressive, hereditary or sporadic diseases of the nervous system. The main feature is the progressive loss of nerve cells ( neurodegeneration ) leading to various neurological symptoms - often including dementia and movement disorders - leads. The disease can occur at different ages, run diffuse or generalized and elicit characteristic histological pattern of damage.

Classification of neurodegenerative diseases by Mackenzie et al.:

Tauopathies:

• Alzheimer's disease (AD)
• Progressive supranuclear palsy ( PSP)
• Corticobasal degeneration ( CBD)
• Silver grain disease ( AGD )
• Frontotemporal dementia and Parkonsonismus of chromosome 17 ( FTDP -17)
• Pick's disease

Synucleinopathies:

• Parkinson's disease (PD )
• Lewy body dementia ( LBD)
• Multiple system atrophy (MSA )

TDP -43 Proteinopathie

• Frontotemporallappen degeneration with TDP -43 ( FTLD - TDP)

FUSopathien

• Frontotemporallappen degeneration with FUS ( FTLD - FUS )
• Neuronal intermediate filament inclusion disease ( NIFID )
• Basophilic inclusion body disease ( BIBD )

Trinukleotiderkrankungen:

• Huntington's disease (HD)
• Spinobulbar muscular atrophy type Kennedy ( SBMA )
• Friedreich's Ataxia
• Spinocerebellar ataxia ( SCA)
• Dentatorubro - Pallidoluysische atrophy ( DRPLA )

Prion diseases:

• Creutzfeldt -Jakob disease
• Gerstmann - Sträussler - Scheinker syndrome
• Fatal familial insomnia
• Kuru

Moto Euro diseases

• Amyotrophic Lateral Sclerosis ( ALS)
• Primary lateral sclerosis
• Spinal muscular atrophy ( SMA)

Neuroaxonal dystrophies

• Infantile Neuroaxonal dystrophy ( Seitelberger disease)
• Neurodegeneration with brain iron accumulation ( NBIA )

Unclassified

• Frontotemporallappen degeneration with ubiquitin -proteasome system ( FTLD -UPS )
• Familial encephalopathy with neuroserpin inclusions