Octenidine dihydrochloride
- N-octyl -1-[ 10 - (4- octyliminopyridin -1-yl ) decyl ] pyridin-4 -imine (IUPAC)
- N, N'-( decane -1 ,10- diyldi -1 ( 4H) -pyridyl -4- ylidene) bis ( octylammonium ) dichloride
- Octenidinum (Latin )
- 71251-02-0
- 70775-75-6 ( dihydrochloride)
- D08AJ57
- G01AX66
Antiseptic
215-217 ° C. ( dihydrochloride)
- 800 mg · kg -1 ( LD50, Rat, oral, dihydrochloride)
- 10 mg · kg -1 ( LD50, rat, iv, dihydrochloride)
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Octenidine is a broad spectrum antiseptic for disinfecting the skin and mucous membranes and to disinfect wounds.
Area of application
Octenidine is for the disinfection of skin and mucosal wounds, usually used together with 2% phenoxyethanol. It is also used before surgery in the anal and genital area as well as in preparation for the laying of a bladder catheter.
Spectrum
Octenidine is bactericidal against both Gram- positive and -negative bacteria, virucidal against lipophilic viruses such as the herpes simplex virus and the hepatitis B virus. In addition, it is fungicidal, but not against spores.
Advantages / Disadvantages
Benefits
- Odorless
- Colorless
- Painless application
- Broad spectrum of activity
- Remanence
Disadvantages
- Cartilage toxicity ( may just as polyhexanide not be applied to cartilage tissue and in the inner ear or in the vicinity of the eardrum )
- Not approved for flushing the abdominal cavity and urinary bladder
- Compared with povidone - iodine comparatively expensive
- Some manufacturers no longer permitted probes for the care of (eg PEG )
- Not for long-term use ( > 2 weeks )
- Not to be used under occlusion
Notes
With simultaneous use of PVP - iodine -based antiseptics may brownish come in the border area to to purple skin discoloration.
When the supply of stab wounds about the hand area - as well as generally in the treatment of wound cavities with Octenidine - it must be ensured that the preparation can flow, as it can lead to massive edema and tissue damage otherwise that may need to be repaired surgically.
Trade names
Octenidine, Octenisept ( with phenoxyethanol ), Octeniderm (with 1 -propanol and 2 -propanol), Octenisept wound gel, mouthwash octenidol