Perforin

  • OMIM: 170280
  • UniProt: P14222
  • MGI: 97551

Perforin ( PRF1 ) is a cytolytic protein ( CD8 positive T lymphocytes ), and NK cells can be found in the granules of cytotoxic T cells. In degranulation it perforates the cell membrane of the target cell and forms a pore. Through this pore Granzyme B penetrate into the target cell and trigger an apoptosis.

Mutations in the PRF1 gene can cause hemophagocytic lymphohistiocytosis type 2 ( FHL2 ).

Human Genome Organisation Mouse Genome Informatics Euteleostomi Granule (cell biology) Digital Object Identifier PubMed Central
641900
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