Peter Nowell
Peter Nowell Carey ( born 1928 in Philadelphia ) is an American pathologist and cancer researcher.
Life and work
Nowell acquired in 1948 at Wesleyan University in Middletown, Connecticut, a bachelor's degree in biochemistry and 1952 at the University of Pennsylvania in Philadelphia an MD as graduation from medical school. After holding several positions as a postdoctoral fellow and the military service of the U.S. Naval Radiological Defense Lab Nowell in 1956 joined the faculty of the University of Pennsylvania. 1964 he received a full professorship of pathology and was from 1967 to 1973 professor of pathology. Nowell was a founding director of the local Cancer Center (about: Cancer Research Center ) ago. 2003 Nowell retired.
Early 1960s was the state of the science, that infection with viruses in a variety of cancer cells can give rise to. Nowell discovered in 1960, the Philadelphia chromosome, the first time a characteristic and regularly encountered chromosome aberration as a cause of cancer ( here for chronic myeloid leukemia, CML) could be identified. As a result, the field of research and the diagnostic field of cancer cytogenetics developed. Nowell developed a now widely accepted model for oncogenesis by multiple genetic changes in a single cell, which ultimately malignant transformed.
Other successes Nowells were discovering that a bone marrow transplant to survive lethal irradiated organisms and that, conversely, a previous irradiation increases the probability of success of bone marrow transplantation. Nowell could also establish the method of inducing cell division of lectins with white blood cells.