Phosphoenolpyruvic acid

2 - ( phosphonooxy ) prop-2- enoic acid

Fixed

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Phosphoenolpyruvic (PEP ), better known as its anionic form phosphoenolpyruvate, is a high-energy metabolic intermediate of glycolysis, gluconeogenesis and the Hatch- Slack cycle of C4 plants. It also plays in humans in some metabolic processes play a role, such as the carbohydrate transport through biomembranes (about the phosphotransferase system ), in the citric acid cycle and glycolysis. It is examined, whether it can be used in the treatment of irritable bowel syndrome ( irritable bowel syndrome, IBS) to alleviate the symptoms.

The acid produced in organisms by dehydration under the catalytic action of enolase, phosphoglycerate or phosphoglycerate, but can in principle be produced by phosphorylation of the enol form of pyruvic acid by supplying energy.

2 -phosphoglycerate splits off a water molecule; it arises phosphoenolpyruvate ( PEP). Because of the resulting double bond the phosphate group of PEP is unstable bound and is easily transferred to ADP to form ATP; from the PEP produced pyruvic acid or pyruvate.

Three salts are known in crystalline form. Sodium pyruvate as the monohydrate can be precipitated from methanol and diethyl ether. The barium salt is known as the hexahydrate, and can be obtained by precipitation from an aqueous alcoholic solution. In addition, barium - silver - pyruvate was obtained as the dihydrate by precipitation from aqueous acetone.

Swell

• Stoffwechselintermediat
• Alkenic
• Phosphoric acid esters