Phosphoglycerate kinase

Phosphoglycerate kinase ( PGK) is the name for the enzyme 3-phosphoglycerate the fabric adds a phosphate group. The reverse reaction, removal of phosphate of 1,3- bisphosphoglycerate is catalyzed by PGK well and is part step of glycolysis, the utilization of carbohydrates in the metabolism of all living beings. Mutations in the PGK gene in humans can lead to PGK deficiency and hemolytic anemia.

With mammals, a second isoform of PGK has developed ( PGK2 ), which is localized exclusively in the testis. It is very likely caused by a copy of the mRNA transcript of the PGK1 gene by reverse transcriptase, called Retrogen. PGK2 is only expressed during spermatogenesis, as a substitute for PGK1, whose gene is located on the X chromosome, and their production, therefore, rests at this stage.

The formation of PGK in particular activated by HIF -1. Another function of the PGK1 outside of glycolysis than disulphide reductase in the formation of blood vessels in tumors, where it is activated by CXCR4. PGK1 is therefore part of the signal transduction.

Catalysed equilibrium

ADP ATP ⇔

Phosphate is transferred from 1,3- bisphosphoglycerate to ADP and vice versa.

Human Genome Organisation 3-Phosphoglyceric acid 1,3-Bisphosphoglyceric acid Protein isoform Hypoxia-inducible factors Adenosine diphosphate Adenosine triphosphate
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