Povidone-iodine
- Polyvinylpyrrolidone - iodine ( PVP - iodine)
- Poly (1 - (2- oxo-1- pyrrolidinyl) ethylene) iodine complex
- D08AG02
- D09AA09
- D11AC06
- G01AX11
- R02AA15
- S01AX18
Yellowish to reddish- brown powder with a characteristic odor
Antiseptic
Fixed
300 ° C.
8100 mg · kg -1 (mouse, peroral ) Template: Infobox Polymer/LD50 not empty
Povidone - iodine ( PVP-iodine, or poly ( 1 - (2- oxo-1- pyrrolidinyl) ethylene) iodine complex ) is a water-soluble complex of iodine with polyvinylpyrrolidone (PVP, povidone ), which is used as a disinfectant or antiseptic.
Structure
Wasserstofftriiodid (H I3 - ) acts as an ion pair within the povidone. The iodide seems to be so bound, that the proton is attached via short bonds to the carbonyl groups of two pyrrolidone rings, while the Triiodidanion is ionically bound to the cation. The positive charge is distributed over the - NCOHOCN bonds the pyrrolidone rings. The left part structure (s ) shows the complexed iodine portion, right (m) the uncomplexed the chain, where n / m = 1/18, i.e., a complexed portion of the polymer chain is not complexed to 18 parts.
Application
A 10 % aqueous solution of povidone - iodine is used as a topical bactericidal, fungicidal, germicidal, and sporozides virucidal disinfectant. However, it has a similar spectrum of activity such as tincture of iodine is more compatible with the skin and mucous membranes. 3% povidone - iodine ( PVP -I) as a liposomal hydrogel shows in wound care compared with conventional PVP-I formulations significantly superior effect.
PVP - iodine has in comparison to modern antiseptics (eg polyhexanide or Octenidine ) no known effect gaps. The rapid onset of microbicidal activity - without organic loading in vitro within 30 seconds - and the good tissue compatibility make PVP - iodine to the " drug of choice for short-term use in infections or contaminated traumatic acute wounds ", where for polyhexanide and Octenidine a " principle of equivalence " was found [ regarding the application of acute infected or colonized wounds ].
However, PVP - iodine is fraught compared to modern antiseptics with various disadvantages that limit its uses. So are rare allergic reactions and systemic side effects (eg, hyperthyroidism ), which is why PVP - iodine, for example, is not intended to be used in ( hyperthyroid ) thyroid disease. Even in pregnancy, lactation, and infants up to 6 months of the application should be carefully considered and, where appropriate, to control the thyroid function. In addition, the wound assessment is made difficult by the brown color of the preparation. Finally, iodine is through contact with blood, pus and wound exudate inactivated (so-called protein error ), which partially obscures the disinfecting effect. For this reason, PVP - iodine in wound care partly replaced by other antiseptics.
Trade names
Betadine (ES, CH, I, NL ), Betadona (A), Betaisodona (D, A), Braunol (D, A, CH), Braunosan (CH), Braunovidon (D, A, CH), Destrobac (CH), Freka - Cid (D), Jodoplex (CH), Polydona (D), Polysept (D), Sepso (D), Topionic ( ES), Traumasept (D), Wundesin (A), Repithel (D)
Betaseptic (D, A, CH), Braunoderm (D, A, CH)