Propylhexedrine

IUPAC: (RS) - (2- cyclohexyl-1 -isopropyl ) methylamine

  • 3595-11-7 [( ±)- Base ]
  • 6192-98-9 [( ±)- hydrochloride ]

Sympathomimetic

0.85 g · cm -3 ( 25 ° C)

  • 80-82 ° C (S- enantiomer, 12 hPa)
  • 92-93 ° C ( 27 hPa, racemate)

4.78 ( pKb )

Sparingly soluble in water, miscible with ethanol, chloroform and diethyl ether

70 mg · kg -1 ( LD50, mouse, ip, ( ±)- hydrochloride)

Template: Infobox chemical / molecular formula search available

Propylhexedrine (also Hexahydrodesoxyephedrin ) is a central nervous stimulant that is marketed in the U.S. as Benzedrex Inhaler. Propylhexedrine is structurally related to methamphetamine. It is mainly used for the symptomatic treatment of nasal discharge associated with colds and allergies.

Synthesis

Propylhexedrine can be prepared by ring hydrogenation of methamphetamine in the presence of platinum ( IV) oxide as a catalyst. A enantiomers are using L-( )- tartaric acid.

CAS registry number PubChem Intraperitoneal injection Allergy Digital Object Identifier
662631
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