Queuosine

• Q ( short code )
• 2-amino- 5-[ {[( 1S, ​​4S, 5R) -4,5- dihydroxy- 1- cyclopent -2-enyl ] amino}- methyl] -7 - [ (2R, 3R, 4S, 5R ) -3 ,4- dihydroxy- 5-( hydroxymethyl )-2- tetrahydrofuranyl ] -1H -pyrrolo [3,2 -e ] pyrimidin- 4-one

Fixed

Template: Infobox chemical / molecular formula search available

Queuosin (Q) is a rare and nucleoside is present in the tRNA of bacteria and eukaryotes. It consists of the β -D - ribofuranose (sugar ) and the Queuin. It is derived as the structurally Archaeosin of guanosine from. The N7 atom of guanine is replaced by a C7 - atom, thereby forming 7- deazaguanosine, may be added to the other substituents.

Queuosin was found in a tRNA from E. coli in 1968, it is found in anticodon at position 34 and occupies the wobble position for histidine, aspartic acid, asparagine and tyrosine. The cyclopentene ring of Queuosins protrudes from the anticodon and thus not hindered base pairing with the codon of the mRNA. There is the possibility of hydrogen bonding between the hydroxyl groups of the cyclopentene ring and the oxygen atoms of the ribose of the uracil at position 33 we compare the bond strengths between codon and anticodon ( guanosine or Queuosin at position 34 ), it is observed that guanosine his usual partner C preferred. The Queuosin can not distinguish between C and U.