Sulfamerazine
4-amino- N- (4-methyl -2-pyrimidinyl ) benzenesulfonamide
- J01ED07
- D06BA06
Yellow- white or pinkish- white, crystalline powder or crystals
Sulfonamides
235 ° C ( decomposition)
7.1 (25 ° C)
- Poorly in water ( 350 mg · l-1 at 37 ° C and pH 5.5, 1.7 g · l-1 at pH 7.5)
- Little in acetone, in ethanol bad, very bad in diethyl ether and chloroform
- Rapidly soluble in dilute mineral acids and sodium, potassium, ammonium hydroxide solutions
Attention
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Sulfamiderazin (trade names among others Trimetox ® vet -. Manufacturer Veyx ) is an antibiotic in a group of sulfonamides, which is especially indicated for infections of respiratory system, urinary tract and ENT area.
In order to cover a broader spectrum, oral preparation forms in combination with trimethoprim are available.
- 2.1 Mechanism of action ( pharmacodynamics )
- 3.1 residue testing
- 3.2 synthesis
- 3.3 purity testing
- 3.4 Storage
Clinical information
Areas of application (indications )
In infections of the respiratory system, urinary tract and ENT area, a combination preparation with trimethoprim used.
Sulfamerazine is used in veterinary medicine.
Interactions with other drugs
The nephrotoxic effect of cyclosporin A can be strengthened.
Adverse effects (side effects)
In essence, the adverse effects are similar to those of sulfadiazine and sulfamethoxazole.
Pharmacological properties
Mechanism of action ( pharmacodynamics )
The effect is based on the competitive enzyme inhibition in the bacteria in the Dihydrofolsäurebildung. Sulfamiderazin acts as p- aminobenzoic acid - antagonist and thus acts bacteriostatic.
Other Information
Residue testing
Sulfamerazine residues in foods (for example, chicken eggs ) from treated animals can be found up to 10 days after treatment.
Synthesis
Sulfamerazine is prepared by condensation of 2- amino-4- methylpyrimidine with Acetylsulfanilylchlorid, followed by hydrolysis of the acetyl group:
Purity testing
The purity of the related substances test is carried out by thin layer chromatography (TLC). According to the European Pharmacopoeia, the detection is performed with fluorescent plates under a UV lamp ( λ = 254 nm), in the then extinction ( dark spot ) caused can be seen through the UV absorption of the sulfamiderazin chromophores. It is also possible to make the substance spots with DMAB ( Ehrlich's reagent), which generates a yellow reaction product after heat treatment, visible:
Storage
Sulfamiderazin should be stored protected from light.
Trade names
Monotherapy is not recommended. Trade names of some combination preparations of sulfamiderazin are:
- Decotox ® (vet ) - Manufacturer ascorbic (IT)
- Trimetox ® (vet ) - Manufacturer Veyx ( DE)
- Berlocombin ® - Manufacturer Berlin-Chemie
Preparations
- Berlocombin ® 100 suspension and Berlocombin ® 200 Tablets