Sulforaphane
- (RS )-1- isothiocyanato -4- methylsulfinylbutan
- (R )-1- isothiocyanato -4- methylsulfinylbutan
- (S )-1- isothiocyanato -4- methylsulfinylbutan
- 4478-93-7 [( RS)- sulforaphane ]
- 142825-10-3 [(R) - sulforaphane ]
- 155320-20-0 [( S)- sulforaphane ]
Slightly yellowish liquid
130-135 ° C (4 Pa)
- Insoluble in water
- Default in DMSO (40 g · l -1)
Template: Infobox chemical / molecular formula search available
Sulforaphane, chemically 1- isothiocyanato -4- methylsulfinyl - butane, is an isothiocyanate. The mustard oil is produced in the enzymatic hydrolysis of glucoraphanin Senfölglykosids.
Properties and Occurrence
Sulforaphane is a powerful indirect antioxidant. It was first isolated in 1992 and described by Paul Talalay and colleagues at Johns Hopkins University in Baltimore.
The phytochemical comes as Senfölglykosid - glucoraphanin in particular in the cruciferous plants such as cabbage and broccoli. In contrast to vitamin C, vitamin E or β -carotene, the active ingredient neutralizes free radicals directly, but indirectly by activating phase II enzymes. This sustainable antioxidant defense mechanisms of the body are set in motion.
Various studies have an inhibitory effect on tumor cells by sulforaphane was detected in both the cell culture and in animal tests. Here are specific components of dividing cancer cells called microtubules are destroyed by sulforaphane, which leads to the demise of the cancer cell. Currently (as of September 2012) is sulforaphane in a variety of clinical studies. Among other things, in a Phase II trial for the treatment of prostate cancer.
In recent experimental studies from the University of Heidelberg and German Cancer Research Center could be shown that the ingredient sulforaphane from broccoli and related vegetables may inhibit cancer growth of pancreatic cancer and enhances the effects of chemotherapy. Sulforaphane this blocked a particular metabolic pathway in cancer stem cells, which could be shown in experiments on cancer cells and mice for the first time. According to a Canadian study is to reduce the metastasis of the tumor by 50 percent in patients with prostate cancer, the weekly consumption of broccoli or cauliflower. In addition, the active substance is germicidal effect against gastric ulcer Helicobacter pylori cause, even against strains that have formed the usual antibiotics resistance.