Tebuconazole

• (RS)- 1-tert- butyl-1- (4- chlorophenethyl ) -2 - ( 1H-1 ,2,4-triazol- 1-yl ) ethanol
• (±)- 1-tert- butyl-1- (4- chlorophenethyl ) -2 - ( 1H-1 ,2,4-triazol- 1-yl ) ethanol
• (±) -1 - ( 4-chlorophenyl) -4,4- dimethyl-3- (1,2,4- triazol-1 -ylmethyl) -pentan- 3-ol

Colorless and odorless solid

Fixed

1.25 g · cm -3

102 ° C

165 ° C ( decomposition)

UPA 3.9 (25 ° C)

• Practically insoluble in water ( 29 mg · l-1 at 20 ° C)
• Very soluble in organic solvents

Attention

• 3350 mg · kg -1 ( LD50, rat, oral)
• 4488 mg · kg -1 ( LD50, chicken, orally )
• > 5000 mg · kg -1 ( LD50, Rabbit, transdermal)

Template: Infobox chemical / molecular formula search available

Tebuconazole is a chemical compound selected from the group of triazoles.

Production and representation

Tebuconazole can be obtained by ring opening of 2-tert- butyl-2- (4- chlorophenethyl ) oxirane with 1,2,4- triazole in the presence of a base.

Stereochemistry

Since tebuconazole contains a stereocenter there are two enantiomers of this drug. Tebuconazole is the technical as a 1:1 mixture (racemate ) of the (R) - and used the (S) form.

Properties

Tebuconazole is a flammable, colorless, odorless solid that is practically insoluble in water. It is stable to hydrolysis at pH's of 5, 7 and 9

Use

Tebuconazole is used as a fungicide. The effect is based on an action of the substance in the metabolism of the fungal cells. The compound was brought to market in 1988.

In the European Union, 2009 pesticides may be authorized for uses as fungicide tebuconazole with since September.

In Germany, Austria and Switzerland pesticides are authorized (eg Folicur ) with this drug.

Tebuconazole is also wood preservatives added as an antifungal agent.