Thymidylate synthase

  • OMIM: 188350
  • MGI: 98878

Thymidylate synthase is an enzyme in the biosynthesis of dTMP ( d for deoxynucleotides; TMP for thymidine monophosphate ) methylated uracil in the form of uridine monophosphate. The presence of sufficient amounts of dTMP is necessary for their replication and DNA repair. The enzyme is therefore a target for cytotoxic drugs such as 5- fluorouracil, pemetrexed and raltitrexed (but not methotrexate) that inhibit it. Resistance to these drugs occurs in individuals who produce an excess of the enzyme. TYMS competes with the enzyme MTHFR, which converts homocysteine ​​to methionine cofactor methylenetetrahydrofolate.

Synthesis

The gene encoding TYMS gene is found in all eukaryotes. It stretches in human exons 6 through 15 kilobases on chromosome 18 The protein is 313 amino acids long and 35.7 kDa heavy.

Catalyzed reaction

The synthesis of dTMP (1b) from dUMP (1a) is catalysed by thymidylate synthase (A). The methylene group derived from N5, N10- methylenetetrahydrofolate (2), which is converted to 7,8- dihydrofolate (3). The rest are R1 is 1 - (2 -deoxy- β -D - ribofuranosyl) -, and R2 is - benzoylglutaminsäure.

Human Genome Organisation Mouse Genome Informatics Transferase Organism Entrez Ensembl UniProt National Center for Biotechnology Information
774514
de