Thyroid peroxidase

  • CAS Number: 9031-28-1

Thyroid peroxidase (TPO) (also: iodide peroxidase, systematic name: iodide peroxide oxidoreductase ) is the enzyme that catalyzes the first reaction step in the synthesis of thyroid hormones from the amino acid tyrosine. The enzyme is produced in all chordates. Defects in the enzyme due to mutations in the TPO gene in humans can lead to special forms of hypothyroidism.

Thyroid peroxidase which is a transmembrane protein that is present in the apical membrane of thyroid cells. In various autoimmune diseases of the thyroid gland ( Autoimmunthyreopathien ) can autoantibodies against thyroid peroxidase which ( thyroid peroxidase antibodies, TPO -Ab ) were detected.

Catalyzed reactions

2 2 I- H2O2 ⇒ 2 2 H2O

Iodide is oxidized to iodine, which substituted immediately to tyrosine.

2 2 I- H2O2 ⇒ 2 2 H2O

Iodide is oxidized to iodine, which immediately substituted 3- iodotyrosine.

Further Reading

  • Lothar Andreas Hotze, Petra -Maria Schumm - Draeger. Thyroid diseases. Diagnosis and therapy. Berlin 2003 ISBN 3-88040-002-4
  • HOSOYA T, KONDO Y, N UI: Peroxidase activity in thyroid gland and partial purification of the enzyme. In: J. Biochem .. 52, September 1962, pp. 180-9. PMID 13,964,156th
  • Loughran NB, O'Connor B, O'Fágáin C, O'Connell MJ: The phylogeny of the mammalian heme peroxidases and the evolution of Their diverse functions. In: BMC Evol. Biol 8, 2008, pp. 101, doi: . 10.1186/1471-2148-8-101. PMID 18371223 PMC: . 2315650 (Free full text ).
  • Song Y, Driessens N, Costa M, et al: Roles of hydrogen peroxide in thyroid physiology and disease. In: J. Clin. Endocrinol. Metab .. 92, No. 10, October 2007, pp. 3764-73. doi: 10.1210/jc.2007-0660. PMID 17,666,482th
Protein isoform Human Genome Organisation CAS registry number Digital Object Identifier PubMed Central European chemical Substances Information System
713016
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