Titia de Lange

Titia de Lange ( b. 1955 in Rotterdam) is a Dutch cell biologist and geneticist at Rockefeller University in New York City.

Life

De Lange studied at the University of Amsterdam, and acquired in 1985 at Nederlands Kanker Instituut at Piet Borst ( NKI, The Netherlands Cancer Institute) a Ph.D. in biochemistry. As a postdoctoral fellow, she worked with Harold Varmus at the University of California, San Francisco. Since 1990 she is a professor at Rockefeller University in New York City, first as an assistant professor and since 1994 as an associate professor. In 1997 she received a full professor since 2011 and co-director of the Anderson Center for Cancer Research. Her research professorship is funded by the American Cancer Society.

Work

De Long work expanded the understanding of telomeres, the ends of chromosomes protected. De Lange was able to identify and discovered that telomeres form a loop most of the known components of the telomeres. As an additional protection mechanism they discovered the shelterin complex. With their work, de Lange has cleared the cellular response to telomere dysfunction and could show how the telomere -associated proteins control the length of the telomeres.

TRF2 and Tin2 as components of Telosom / shelterin complex

Shelterin cell cycle

Awards (selection)

• 2000 Corresponding Member of the Royal Netherlands Academy of Sciences
• 2001 Member of the European Molecular Biology Organization
• 2003 Honorary doctorate from the University of Utrecht
• 2006 Foreign Member of the National Academy of Sciences
• 2007 Member of the American Academy of Arts and Sciences
• 2007 Elected Member ( Fellow ) of the American Association for the Advancement of Science
• 2010 Harvey Lecture
• 2012 HP Heineken Prize for Biochemistry and Biophysics
• 2013, it was among the first winners of the Breakthrough Prize in Life Sciences.
• 2014 Canada Gairdner International Award