Uridine monophosphate

Fixed

202 ° C ( decomposition)

• Readily soluble in water
• Soluble in methanol

> 1 g · kg -1 ( LD50, mouse, ip)

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When uridine or uridylate is called the monophosphate of uridine. It belongs to the group of nucleotides and is present in all living things. Uridine is the most important intermediate in the pyrimidine biosynthesis. All other pyrimidine nucleotides are formed from UMP and it in turn is produced during biodegradation.

The phosphate group bound to deoxyribose, one speaks of deoxyuridine monophosphate or deoxyuridylate ( dUMP ), which is an intermediate in the biosynthesis of the DNA nucleotide deoxythymidine triphosphate ( dTTP ) is.

Biosynthesis and function

UMP is obtained in the metabolism except by dephosphorylation of UDP and UTP by several synthetic routes. The main path, de novo synthesis, starting with glutamine and carbamoyl and extending over orotate to orotidine -5' -monophosphate ( OMP), which is implemented using the enzyme orotidine -5'-phosphate decarboxylase to UMP.

Another possibility is to use the uridine kinase phosphorylation of uridine. Moreover, it is also available directly from uracil, wherein the reaction with phosphoribosyl pyrophosphate ( PRPP ) which is catalysed by uracil phosphoribosyltransferase.

UMP last produced or by-produced in the metabolism of certain bacteria, in the biosynthesis of peptidoglycan ( EC 2.7.8.6, EC 2.7.8.13 etc.) and the degradation of UDP-glucose ( EC 3.6.1.45 ).