Xiaodong Wang

Xiaodong Wang (Chinese王晓东/王晓东, Pinyin Wang Xiǎodōng; * 1963 in Wuhan, People's Republic of China ) is an American biochemist and molecular biologist.

Life

Wang received in 1984 from the Beijing Normal University with a degree in Biology and in 1991 with Richard Padgett at the University of Texas Southwestern Medical Center a Ph.D. in biochemistry. As a postdoctoral fellow he worked with Nobel laureates Michael S. Brown and Joseph L. Goldstein for cholesterol regulation by the protein SREBP. 1995 Wang received at the Department of Biochemistry at Emory University in Atlanta, Georgia, a first professorship ( Assistant Professor ) and our own laboratory, where he began to get to grips with apoptosis and its regulation. In 1996, Wang returned to the University of Texas Southwestern Medical Center at the local new head of the biochemistry, Steve McKnight. Since 1997, Wang conducts research in addition to the Howard Hughes Medical Institute.

Today (2012 ) researches Wang at the National Institute of Biological Sciences in Beijing, whose co-director he is. Wang is married.

Work

Wang is a pioneer in the study of effector mechanisms of apoptosis that take place in the cytosol along the mitochondria. Wang identified and characterized the apoptosome -called complex of cytochrome c, Apaf -1 and caspase -9, which induces cell death. In addition, Wang discovered other regulatory proteins of apoptosis, including DFF, EndoG and SMAC. Wang's research showed out a metabolic pathway in the mitochondrion and nucleus into and out of these.

Awards (selection)

Michael Stuart Brown Sterol regulatory element-binding protein Georgia (U.S. state)
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