Adoptive cell transfer

Adoptive cell transfer refers to the transfer of cells into an organism.

Properties

By the treatment of cells ex vivo with a vector containing immunogen or drug effects can be obtained that are not always achieved in vivo. For example, a drug used to treat prematurely in the organism (e.g., the liver) or are eliminated or reduced drug toxicity develops only in the body. Transfer the cell consists of a collection of cells ( whether autologous or autologous), the treatment of ex vivo, and their transfer, usually by injection or infusion into an organism. Through the transfer or autologous cells by the retransfer of the organism receives cells with new functions, where the name comes adoptively.

In Immunology usually autologous immune cells ( PBMC thereof especially T lymphocytes and dendritic cells) are isolated by density gradient centrifugation and then treated in cell culture. This treatment of the cells can stimulate in vaccines (including with IL- 2, GM-CSF, IL-12, IL -21) or tolerogenic Hyposensitizations (e.g., anti-CD3 antibodies such as muromonab - receptor CD3, otelixizumab, teplizumab and Visilizumab ) be.

Applications

Adoptive cell transfer is used, among others, in gene therapy in stem cell therapy or immunotherapy.

In the context of ex vivo immunotherapy is immunized against tumor cells, inter alia.