He began at the age of 11 years with the karting. He was runner-up in the Italian Championship, won championships at national level and in CIAK Cup and 2000 was second in the 125 Italian championship. At the age of 19 years, Andrea Bertolini was a test driver of road vehicles at Ferrari. Since 2009 he is also the racing team in this function.
In 2001 he drove a Porsche 996 GT3 -R in the GT2 class of the FIA GT Championship. In 2002 and 2003 he went with a Ferrari 360 Modena in the team JMB Racing at the start. 2004 moved to Pour Squadra Corse team Bertolini, where he also drove a 360 Modena. In the championship, he finished second and received the " Performance Driver of the Year " award.
In the second half of 2004, Bertolini went along with Mika Salo of the mitentwickleten him GT1 Maserati MC12 Maserati for the team AF Corse in four races in the FIA GT Championship. At Oschersleben and Zhuhai, the duo was able to win.
Together with the former Formula 1 racing driver Karl Wendlinger took Bertolini 2005 with a JMB Racing MC12 in the FIA GT Championship in part and finished fourth in the GT1 Drivers' Championship. He also drove the entire season of the American Le Mans Series ( ALMS) for Risi Competizione, although the MC12 is not homologated there, and therefore not entitled to points, was.
From 2006 - with an interruption in 2007, in which he drove at Scuderia Play team Sara Free - up to and including 2010, Bertolini drove to the side of Michael Bartels in the Vitaphone Racing Team Maserati MC12 with a. 2006, 2008 and 2009, won Bertolini and Bartels, the FIA GT Championship. With a guest appearance for Doran Racing in the ALMS Bertolini scored the pole position at Road America and was instrumental in second place in the GT1 category at that race involved.
The newly advertised FIA GT1 World Championship could Bartels and Bertolini also decide for himself and bestowed the Maserati MC12 the last title before the vehicle was no longer permitted because of the non-extended homologation for the GT1 category.
2011 won the International Superstars Series Bertolini with a Maserati Quattroporte for the Swiss team. 2010 and 2011 he also took part in selected races of the Trofeo Maserati Europe, of which he could win some.
Bertolini in 2005 had completed a guest stint in the ALMS for JMB Racing, but since the year 2011 Bertolini runs regularly race with Ferrari. In 2012 he started together with Olivier Beretta in the FIA World Endurance Championship and Le Mans. With JMW Motorsport Bertolini joined in 2013 again at Le Mans.
In the Blancpain Endurance Series Bertolini has been active since 2011. In 2011 he drove a race for Vita4One, 2012 and 2013 regularly for AF Corse. In the Pro-Am Cup in 2012, he was runner-up, although he auslies two of the six races of the season.