Erich Nigg

Erich Nigg ( born November 28, 1952 in Uster) is a Swiss cell biologist and director of the Biozentrum, University of Basel.

Life

Erich Nigg his doctorate in 1980 at the ETH Zurich ( Biochemistry). He subsequently did research at the University of California at San Diego, the ETH Zurich and the Swiss Institute for Experimental Cancer Research ( ISREC ). From 1995 he was a professor of molecular biology at the University of Geneva before 1999, he became director of the Max Planck Institute for Biochemistry in Martinsried ( Germany ). Since 2009, Erich Nigg is a professor of cell biology and director of the Biozentrum, University of Basel.

Work

After early work on biological membranes, the structure of the nucleus as well as mechanisms of signal transduction in the cell nucleus, Erich Nigg focused on the study of the cell cycle. His research results are fundamental to understanding the distribution of human chromosomes during cell division, control of mitosis, and the elucidation of the structure and function of centrosomes. These works are medically relevant, as disturbances in mitosis contribute to genetic instability of cancer cells and centrosome abnormalities cause disease ( brain diseases and ciliopathies ). In addition, control of the cell cycle are enzymes (protein kinases) as attractive targets for new therapeutic agents.

Awards

List of publications

  • Nigg E, Cherry RJ. Dimeric association of band 3 in the erythrocyte membrane demostrated by protein diffusion measurements. Nature. 1979 277 ( 5696 ) :493 - fourth
  • Nigg EA, Shepherd G, Hilz H, Eppenberger HM. Cyclic -AMP - dependent protein kinase type II is associated with the Golgi complex and with centro somes. Cell. 1985 41 ( 3) :1039 - 51st
  • Borer RA, Lehner CF, Eppenberger HM, Nigg EA. Major nucleolar proteins shuttle in between nucleus and cytoplasm. Cell. 1989 56 (3) :379 -90.
  • Peter M, Nakagawa J, Doree M, Labbe JC, Nigg EA. Identification of major nucleolar proteins as candidate mitotic substrate of cdc2 kinase. Cell. 1990 60 ( 5) :791 - 801.
  • Peter M, Nakagawa J, Doree M, Labbe JC, Nigg EA. In vitro disassembly of the nuclear lamina and M phase -specific phosphorylation of lamins by cdc2 kinase. Cell. 1990 61 ( 4) :591 - 602.
  • Schmidt- Zachmann MS, Dargemont C, Kühn LC, Nigg EA. Nuclear export of proteins: the role of nuclear retention. Cell. 1993 74 ( 3) :493 - 504.
  • Blangy A, Lane HA, d' Hérin P, Harper M, Kress M, Nigg EA. Phosphorylation by p34cdc2 Regulates spindle association of human Eg5, a kinesin -related motor essential for bipolar spindle formation in vivo. Cell. 1995 83 (7) :1159 -69.
  • Meraldi P, Lukas J, Fry AM, Bartek J, Nigg EA. Centrosome duplication in mammalian somatic cells requires E2F and Cdk2 - cyclin A. Nat Cell Biol 1999 1 ( 2) :88 - 93rd
  • Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M. Proteomic characterization of the human centrosome by protein correlation profiling. Nature. 2003 426 ( 6966 ) :570 - fourth
  • Casenghi M, Meraldi P, Wine Hart U, Duncan PI, grains R, Nigg EA. Polo-like kinase 1 Regulates Nlp, a centrosome protein Involved in microtubule nucleation. Dev Cell. 2003 5 ( 1) :113 - 25th
  • Habedanck R, Stierhof YD, Wilkinson CJ, Nigg EA. The Polo kinase Plk4 functions in centriole duplication. Nat Cell Biol 2005 7 (11 ) :1140 - sixth
  • Baumann C, Körner R, Hofmann K, Nigg EA. PICH, a centromere -associated SnF2 family ATPase, is regulated by Plk1 and required for the spindle checkpoint. Cell. 2007 128 ( 1) :101 - 14th
  • Kleylein - son J, Westendorf J, Le Clech M, Habedanck R, Stierhof YD, Nigg EA. Plk4 -induced centriole biogenesis in human cells. Dev Cell. 2007 13 ( 2) :190 - 202.
  • Santa Maria A, Wang B, Elowe S, Malik R, Zhang F, Bauer M, Schmidt A, Silljé HH, grains R, Nigg EA. The Plk1 -dependent phosphoproteome of the early mitotic spindle. Mol Cell Proteomics. 2011 10 (1): M110.004457.
Academia Europaea
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