Furosemide

4- chloro-2- furfurylamino -5 -sulfamoyl -benzoic acid

C03CA01

Loop diuretic

Inhibition of the Na -K - 2Cl - symporter

206 ° C

151 ± 7 mg · l-1 (pH 4.5)

Risk

800 mg · kg -1 ( LD50, rabbit, oral)

Template: Infobox chemical / molecular formula search available

Furosemide is a drug and representatives of the so-called loop diuretics, in the kidney, a transport protein inhibit the ascending limb of Henle's loop ( the Na-K- 2Cl cotransporter ) and thus lead to excretion of large amounts of tissue fluid. With intravenous administration of the drug excretion amounts are possible up to 50 liters per day. It is a strong diuretic. Furosemide was patented in 1962 by Hoechst.

Chemical Properties

When taken orally, furosemide is divided due to its poor solubility and poor permeability in the class IV in Biopharmaceutics Classification System. The poor solubility is primarily due to the acidity which causes a very poor solubility at low pH values. At neutral pH furosemide is somewhat soluble. The poor permeability is partly due to the affinity to an intestinal efflux pump, which is, however, not yet described in detail.

Indications

According to the manufacturer officially approved indications are hypertension, ascites and edema (including brain edema ) as a result of heart failure or due to liver disease, kidney disease or burns, under certain circumstances threatening kidney failure. In addition, furosemide is used for hyperkalemia to flush out excess potassium.

In sports, it is used as a masking agent because it helps flush out any existing traces of occupied doping substances from the body, and is therefore placed on the doping list.

Contraindications

Contraindications are: hypovolemia, anuria, hypokalemia, use during lactation and the hepatic coma.

To side effects see Article loop diuretic.

Trade names

Diurapid (D), Furanthril (D), Furobeta (D), Furodrix (CH), Furogamma (D), Furon (A), Furorese (D), Furosal (D), Fursol (CH), Fusid (D), Jufurix (D), Lasix (D, A, CH), Oedemex (CH ), various generics (D, A, CH)

Beta semid (D), Diaphal (D), Furorese comp ( D), Furo - spiro plane ( A), Furospir (CH), Lasilacton (A, CH), Lasitace (A), Osyrol - Lasix (D), spiro comp ( D), spiro -D ( D)