Gerald Crabtree
Rodney Gerald Crabtree ( born December 18, 1946) is an American cell biologist.
Life and work
Crabtree grew up on a small farm in Potrock Hollow, West Virginia. He studied chemistry and mathematics at West Liberty State College, West Liberty, where he earned his bachelor's degree in 1968. He received his doctorate from Temple University Medical School for MD 1972. When Allan Munck he later worked on the biochemistry of steroids. From 1979 to 1982 he was Assistant Professor of Pathology at the Dartmouth Medical School in Hanover. After two years at the National Institutes of Health in 1985 he was an adjunct professor of pathology at the School of Medicine at Stanford University. Since 1993, he is just there, professor of pathology and developmental biology, and since 1994, he also conducts research at the Howard Hughes Medical Institute.
It examines the interaction between cells and their environment. In the 1980s he discovered the hepatocyte nuclear factor 1 and the nuclear factor of activated T cells (NF -AT) and was able to demonstrate the mechanism of action of cyclosporine. In 1991 started working with Stuart Schreiber he could find among others the Informationstransportweg from cell membrane to the nucleus, the calcium - calcineurin - NFAT pathway. This is important for bone development and the production of insulin. This opens up new treatments for diabetes and osteoporosis.
Publications
Crabtree has published more than 125 scientific papers.