Heinz Falk

Heinz Falk ( born April 29, 1939 in St. Pölten ) is an Austrian chemist, emeritus professor of organic chemistry at the Johannes Kepler University Linz and editor of the series "Progress in the Chemistry of Organic Natural Compounds".

Falk's research focuses on the structural analysis, synthesis, stereochemistry and photochemistry of plant and animal light-sensitive dyes, such as hypericin.

Life

Falk was born on 29 April 1939 in St. Pölten, the elementary school attended in Statzendorf and then the main school in Krems on the Danube. After he moved in 1953 to Vienna, he graduated from the Federal College and Research Institute for Chemical Industry in the Rosensteingasse and then made ​​1959 A-levels in the evening school, where he and his future wife, Rotraud Falk (born straw Bach) met.

Falk is married since 1966 with Rotraud Falk and they have a son (Alexander Falk, CEO of the software company Altova ).

Falk began in 1959 his studies in chemistry at the University of Vienna and in 1966 received his doctorate, with Karl Schlögl was his mentor. As a result, Falk spent the year 1971 as a postdoctoral researcher at ETH Zurich. After his return to Vienna he reached in 1972, the Habilitation and therefore licensed to teach organic chemistry at the University of Vienna.

Career

Since 1966, Falk worked as an assistant at the Institute for Organic Chemistry at the University of Vienna. In 1975 he was appointed associate professor of Physical Organic Chemistry at the University of Vienna. In the summer of 1978, Falk was invited as a speaker to the Gordon Research Conference in Wolfeboro.

1979 Falk took an appointment as Full Professor of Organic Chemistry at the Johannes Kepler University Linz, where he established the new Institute for Organic Chemistry at. From 1989 to 1991 he was Dean of Engineering and Natural Sciences. In 2005, Falk was called by the Upper Austrian News in third place among the top 10 scientists in Upper Austria.

Falk's research focus concentrates on the group of organic dyes from phenanthro [ 1,10,9,8 - opqra ] derived perylene -7 ,14 -dione chromophore, such as the natural dyes hypericin, stentorin, fringelites, Gymnochrome and blepharismin. Moreover, Falk treated the hemin Corrphycen analog derivatives (e.g., as a potential blood substitute and heme oxygenase -blocker ) and other natural compounds such as natural sunscreen factor urocanic acid.

His scientific research results published in two books and more than 300 published articles in refereed journals Falk.

Works

  • Heinz Falk: Selected exercises to Nomenclature of Organic Compounds. Springer -Verlag, Vienna, New York 1978, ISBN 0387814795th
  • Heinz Falk: The Chemistry of Linear Oligopyrroles and Bile Pigments. Springer -Verlag, Vienna, New York, 1989, ISBN 0387821120th

Scientific publications (selection)

  • H. Falk and H. Marko, Reduction of α - Bilindione -10 -thiol adduct as a model for the reduction of the biliverdin reductase Step System. Monatsh. Chem 122, 319 (1991)
  • U. Wagner, C. Kratky, H. Falk and H. Woess, Crystal Structure and Conformation of 10 -aryl- bilatrienes -abc. Monatsh. Chem 122, 749 (1991 )
  • H. Falk and W. Schmitz Berger, On the Nature of " Soluble " hypericin in Hypericum species. Monatsh. Chem, 123, 731 ( 1992)
  • C. Etzlstorfer, H. Falk, N. Mueller, W. Schmitz Berger and U. Wagner, tautomerism and Stereochemistry of hypericin: Forcefield, NMR, and X -ray Crystallographic Investigations. Monatsh. Chem, 124, 751 ( 1993)
  • H. Falk, C. Kratky, N. Mueller, W. Schmitz Berger and U. Wagner, Structure determination of the biliverdin apomyoglobin complex. Crystal Structure Analysis of Two Crystal Forms at 1.4 and 1.5 * Resolution. J. Mol Biol 247, 326 (1995)
  • H. Falk, From the photosensitizer hypericin to the photoreceptor stentorin - the Chemistry of the Phenanthroperylene Quinones. Angew. Chemie Int. Ed. , 38, 3134-3154 (1999)
  • R. A. Upper Müller, K. Hohenthanner, and H. Falk, Towards hypericin -derived potential Photdynamic Therapy Agents. Photochem. Photobiol. , 74, 211-215 (2001)
  • J. Leonhartsberger and H. Falk, The protonation and deprotonation equilibria of hypericin Revisited. Mh Chem, 133, 167-172 (2002)
  • M. Deak and H. Falk, On the Chemistry of the Resveratrol diastereomer. Mh Chem, 134, 883-888 (2003)
  • Beate Hager, Mario Alva Astudillo, and Heinz Falk, A hemin - Analogous Corrphycene Derivative: Suppression of Heme Oxygenase and Reconstitution with apomyoglobin. Mh Chem, 134, 1499-1507 (2003)
  • Klaus Wolkenstein, Jürgen H. Gross, Heinz Falk, and Heinz F. Scholer, Preservation of hypericin and related polycyclic quinone pigments in fossil crinoids. Proceedings of the Royal Society B, 273, 451-456 (2006)
  • Mario Waser and Heinz Falk, Towards Second Generation Hypericin Based Photosensitizers for Photodynamic Therapy. Curr. Org Chem 11: 547-558 (2007)
  • M. Waser and H. Falk, Progress in the Chemistry of Second Generation Hypericin Based Photosensitizers. Curr. Org Chem 15: 3894-3907 (2012 )
  • I. Teasdale, M. Waser, S. Wilfert, H. Falk, O. Bruggemann, Photoreactive, Water - soluble conjugates ofHypericin with Polyphosphazenes. Monatsh. Chem 143: 355-360 (2012 )

Patents

  • Process for the N- alkylation or ureas U.S. Pat 5124451 - July 10, 1991 - Chemie Linz GmbH
  • Process for the N- alkylation of ureas U.S. Pat 5169954 - December 16, 1991 - Chemie Linz GmbH
  • Process for the preparation of pure N, N'- asymmetrically Substituted phenylureas U.S. Pat 5283362 - July 31, 1992 - Chemie Linz GmbH
  • Process for the preparation of isocyanic Acid by Decomposition of N, N- trisubstituted Ureas Eur Pat EP 0582863A2 - February 16, 1994 - U.S. Patent No. 5,360,601 November 1, 1994 - Chemie Linz GmbH
  • Isocyanates by Decomposition of N, N, N- trisubstituted Ureas Eur Pat EP 0583637A1 - February 23, 1994 - Chemie Linz GmbH
  • Amine oxides U.S. Pat 5409532 - JANUARY 21 1993 - Lenzing AG

Awards

  • Theodor Körner Prize for the Promotion of Science and Art, 1970
  • Ernst Späth Prize of the Austrian Academy of Sciences, 1976
  • Price Sandoz, 1977
  • Appointment as a corresponding member of the New York Academy of Sciences, 1989
  • Appointment as a corresponding member of the mathematics and science class at the Austrian Academy of Sciences, 1992
  • Oberösterreichischer country Culture Award for Science, 1993
  • Appointment as full member of the mathematics and science class at the Austrian Academy of Sciences, 1997
  • Josef Loschmidt Medal of the Austrian Chemical Society, 1998
  • Appointment as a member of the European Academy of Sciences, 2003
  • Science Award of Rudolf Trauner Foundation, 2003
  • Silver Medal of the Province of Upper Austria, 2009
Chief Executive Officer Wolfeboro, New Hampshire Dean (education) Johann Josef Loschmidt
382940
de