Hydroxyzine
- (±) -5 - [4 - (4- Chlorbenzhydryl ) piperazin-1 -yl] - 3- oxapentane -1-ol
- C21H27ClN2O2 ( hydroxyzine )
- C21H27ClN2O2 · 2 HCl ( hydroxyzine dihydrochloride · )
- 68-88-2 ( hydroxyzine )
- 2192-20-3 ( hydroxyzine dihydrochloride · )
N05BB01
- Anxiolytics
- Antihistamines
- 374.90 g · mol -1 ( hydroxyzine )
- 447.83 g · mol -1 ( · hydroxyzine dihydrochloride)
193 ° C ( hydroxyzine dihydrochloride · )
Attention
Hydroxyzine (trade name: inter alia, Atarax ®, manufactured by UCB) emotional and mental restlessness, as well as initiating and maintaining sleep is used to relieve anxiety of mental and physical diseases, for the treatment of stress states are used. It is a drug from the group of histamine H1 antagonists of the first generation and therefore can be prescribed as a symptom of various skin diseases even with intense itching, provided the same is desired a strong sedative, psychotropic effect.
Areas of application
- Anxiety in the context of mental and other diseases
- Expectation fears example before an operation or investigation
- Excitation and voltage conditions
- Sleep
- Severe allergic diseases such as Hives ( urticaria ) and atopic dermatitis
In clinical trials, the drug also showed a marked ordering effect on disordered thought patterns in the context of mental disorders.
Operation
The drug hydroxyzine influenced as clinically effective antagonist the neurotransmitter histamine H1 systems, serotonin 5 - HT2, dopamine D1/D2 and the α1 -adrenoceptors in the brain and in the rest of the body. Thus it acts pronounced anxiolytic, sedative (on the emotional life and thinking ) and sedative. Clinical studies after its launch in the 1950s demonstrated together with a strong anxiolytic effect and significant anti-psychotic and thought disorder and obsessive-compulsive disorders affecting positive effects. Due to the simultaneous introduction of typical neuroleptics, however, never came to a regulatory filing for these indications.
In addition, the active ingredient nausea shows diminishing properties and, by blocking the histamine H1 - receptors, a pronounced itching relieving effect.