Nasir Hussain began as a screenwriter with the film company Filmistan and was among other things the author Subodh Mukherjee - movies Munimji (1955) and Paying Guest (1957). He made his directorial debut in 1957 with Tumsa Nahin Dekha, the first film success of Shammi Kapoor. After he was still spinning with Dil Deke Dekho a slightly modified version of his debut film for Filmalaya, he in 1960 founded his own film company " Nasir Hussain film ." He specialized in romantic films, including Jab Pyar Kisise Hota Hai (1961 ) with Dev Anand and Asha Parekh and Yaadon Ki Baraat (1973 ) with Dharmendra and Zeenat Aman.
By 1980, Hussain turned three films in Bhojpuri. Middle of the decade, he retired from directing. In 1988 he was successful with Qayamat Se Qayamat Tak his production and received a Filmfare Award for Best Picture. Nasir Hussain's son Mansoor Khan led to this film directing and his nephew Aamir Khan began his career. He repeated the success with both Jo Jeeta Wohi Sikandar (1993).