Philip Palmer Green

Philip Palmer Green ( born July 5, 1950 in Durham, North Carolina) is an American mathematician and geneticist at the University of Washington in Seattle, Washington.

Life

Green acquired in 1972 at Harvard University in Cambridge, Massachusetts, and a bachelor in 1976 at the University of California at Berkeley, a Ph.D. in mathematics. He received in 1976 a professorship ( Assistant Professor ) of Mathematics at Columbia University in New York City and was 1977/78 guest member at the Institute for Advanced Study (IAS ) in Princeton, New Jersey.

Green then turned to biology and worked as a postdoctoral fellow in the Department of Pathology at the University of North Carolina at Chapel Hill before he places on Collaborative Research Inc., Waltham, Massachusetts, and in the Department of Genetics, Washington University in St. Louis, Missouri, took over. Since 1992 he has been at the University of Washington in Seattle, Washington. He is a professor of genome research, and bioengineering and computer science. In addition, Green Conducting research for the Howard Hughes Medical Institute.

Work

Green developed important computer programs that enabled the systematic and automated analysis of complex genomes. Its computation strategies provided the basis for gene mapping and sequencing of the human genome including (Human Genome Project). Also important insights into the genetic evolution could be obtained. Green realized that only a small fraction of genes is sufficiently slow to develop, so that sufficient obtain similar sequences to be detected in phylogenetically distant organisms as related to ( homology). Green was one of the first to recognize that the number of human genes must be considerably lower than the previously estimated number of 100,000.

Awards (selection)

• 2001 Membership in the National Academy of Sciences
• 2002 Gairdner Foundation International Award

• Membership in the American Association for the Advancement of Science ( Fellow )

Writings (selection )

• AF Neuwald, P. Green: Detecting patterns in protein sequences. J. Mol Biol 239:698-712 1994.
• P. Green: Ancient conserved regions in gene sequences. Curr. Opin. Struct. Biol 1995 4:404-412.
• B. Ewing, P. Green: Base calling of automated sequencer traces using Phred. II error probabilities. Genome Res 1998 8:186-194.
• P. Green, E. Koonin: Genomes and evolution: glimpses of an emerging synthesis. Curr. Opin. Genet. Dev 1999 9: 621-623.
• B. Ewing, P. Green: Analysis of expressed sequence tags indicates 35,000 human genes. Nature Genetics 2000 25: 232-234.