Prostaglandin D2

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Prostaglandin D2 ( or short: PGD2 ) is one of the prostaglandins. It is formed by the prostaglandin D synthase from PGH2. It belongs to the tissue hormones, activates the membrane-bound DP receptor and causes the cells in the increased formation of cAMP. In the mammalian organism large amounts of PGD2 are with androgenetic alopecia found in mast cells and in the brain and, increasingly, in the scalp of humans. Prostaglandin F2a is believed that it counteracts the PGD2 at alopecia.

Effects

  • PGD2 causes (together with thromboxane and PGF2 ), a contraction of the bronchial airways and amplifies a response to other bronchoconstrictors in asthmatic patients. The concentration of PGD2 and TXA2 in the bronchial asthmatic patients is 10 -fold higher than in control patients, especially after coming in contact with allergens.
  • PGD2 lowers the body temperature.
  • PGD2 affects sleep-. Patients with systemic mastocytosis a deep sleep when their mast cells had produced large amounts of PGD2.
  • PGD2 was 2012 - identified on the basis of experiments in human tissue culture and in mice as a probable cause of hereditary hair loss in men ( androgenetic alopecia ) - in cooperation with the steroid hormone dihydrotestosterone ( DHT).
  • PGD2 PGE2 acts to partially counter.
CAS registry number PubChem Prostaglandin H2 Prostaglandin D2 receptor Digital Object Identifier
662619
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