Robert A. Good
Robert Alan Good ( born May 21, 1922 in Crosby, Crow Wing County, Minnesota, † 13 June 2003 in St. Petersburg, Florida) was an American physician ( Immunology ), who was a pioneer in bone marrow transplantation.
Life
Good studied medicine at the University of Minnesota with a bachelor's degree in 1944 and the MD Degree and doctorate ( Ph.D. ) in 1947. As a student, he suffered a polio - like illness that made him partially paralyzed and forced her into a wheelchair and left behind by the later a walking difficulties. Good underwent specialist training in pediatrics at the Hospital of the University of Minnesota. After a year in 1949 at the Rockefeller Institute for Medical Research in New York City (with Maclyn McCarty, Henry Kunkel ) he was again in 1950 at the University of Minnesota, where he conducted research in immunology (especially hereditary immunodeficiencies, but also phylogeny of the immune system in the animal kingdom ) und1962 professor of pediatrics, microbiology and pathology was. At times, he stood in front of the Department Pathology. In 1969 he became Regent's Professor. He became director of the Sloan -Kettering Institute of Cancer Research in New York City in 1972. In 1982 he was in Cancer Research at the Oklahoma Medical Research Foundation in Oklahoma City and from 1985 he was chief physician at All Children 's Hospital in St. Petersburg, Florida and Chairman of the Department of Pediatrics at the University of South Florida Medical School.
Good pioneer in immunology and found with his staff, the cellular basis of many innate immune deficiencies. His research led in particular to the fact that the central role of the thymus was recognized for the development of the human immune system and the role of two major cell lines in the immune system, B cells and T cells. A rare, congenital immunodeficiency, now known as Good's syndrome, played here at the beginning of a particular role.
He also explored, among others, the influence of nutrition on the immune system (and breast cancer) and the immunosuppressive effect of retroviruses. Already in the 1940s, he showed that the herpes virus can be " activated" by anaphylactic shock from its latent phase.
Good demonstrated in animal models ( mice ) that certain congenital immunodeficiencies completely (with the prior removal of certain lymphocytes) can be cured by bone marrow transplantation. In 1968, he led one of the first successful bone marrow transplants as a therapy not due to cancer. He gave a five- month-old boy's bone marrow to his sister. The boy suffered from an inherited immune deficiency, which had already fallen eleven other ( male ) family members of the victim. Due to the transplant, the patient was permanently cured.
He was a member of the National Academy of Sciences and of the Institute of Medicine and the American Academy of Arts and Sciences. In the years 1975/1976 he served as president of the American Association of Immunologists. In 1970 he received the Albert Lasker Award for Clinical Medical Research, the Gairdner Foundation International Award and the 1972 American College of Physicians Award. In 1975 he received the William B. Coley Award from the Cancer Research Institute and the 1987 John Howland Award of the American Pediatric Society.
In his time at the Sloan Kettering Institute a well-known scientific fraud case of its employees, the skin grafts in mice fell by pretending by their colored fur ( William T. Summerlin, uncovered 1974).