In her career, she was in 1990 in the final of Wimbledon women's singles, she has won three Grand Slam titles in mixed doubles and 1988, the gold medal in women's doubles at the Olympic Games in Seoul.
At age ten she started playing tennis, with twelve, she won her first tournament at 14, she won the national championships for 18- year-old. In 1981, she won both the Wimbledon Championships and the U.S. Open juniors and was listed as number 1 in the world rankings.
1982 Garrison became a professional player. Immediately upon their first appearance at the French Open, she reached the quarter-finals, in which they failed due to the eventual tournament champion Martina Navratilova.
In 1983, she came at the Australian Open semi-finals and ended the year ranked 10 in the world rankings.
In 1987 she won the Australian Open along with Sherwood Stewart the Mixed with Lori McNeil they reached the final in women's doubles. The following year she won with him the Mixed Competition of Wimbledon.
With Pam Shriver won in 1988 for the United States at the Olympic Games gold medal in women's doubles when they defeated Jana Novotná in the final there and Helena Suková in three sets. In individual Garrison won the bronze medal after she had turned her doubles partner Pam Shriver in the quarterfinals.
1989 Garrison defeated in the quarterfinals of the U.S. Open Chris Evert, who then never re-enter as a professional player a tennis court. In the same year Zina Garrison finished the season at No. 4 in the world rankings.
Peak of their athletes career was the finals of Wimbledon in 1990, when she the French Open champion Monica Seles in the semifinals and defending champion Steffi Graf defeated in the quarterfinals. In the final, they then defeated Martina Navratilova. In mixed, however, she won her third Grand Slam title together with Rick Leach.
In 1992, she reached with Mary Joe Fernandez once again the final of the Australian Open in women's doubles.
In 1993 she founded the Zina Garrison Academy, which makes possible for underprivileged children from her hometown Houston learning the tennis game.
Zina Garrison in 1996 ended her professional career in which she won 14 singles and 20 doubles titles.