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- June 22 168 BC: The Roman army under Aemilius Paullus succeeds after three years of warfare to defeat the Macedonian armed forces of Pydna in Greece and thus to destroy the Diadochenreich the Antigonid.
- 165 BC: The revolt of the Maccabees against the kingdom of the Seleucids. The revolt was successful and led to the founding of the Jewish kingdom of the Hasmoneans.