Wayans made his acting debut in 1984 in Beverly Hills Cop - I releasable ' the event in any case. A year later he became a member of Saturday Night Live. In 1988 he played the role of aliens Zeebo in the comedy Zebo, the third from the star center alongside Geena Davis, Jeff Goldblum and Jim Carrey. In the years 1990 to 1992 Damon Wayans was seen together with his siblings Keenen Ivory, Kim, Marlon and Shawn in the sketch comedy In Living Color for this role he was nominated in 1990, 1991 and 1992 for the Emmy.
For the lead role in the television series What's Up, Dad? he won in 2002 the People's Choice Award. He was nominated in 2003 and 2005 for a Golden Satellite Award. In the years 2002 to 2005 he was nominated for an Image Award.