Carolyn R. Bertozzi

Carolyn Ruth Bertozzi ( born May 19, 1966 in Boston, Massachusetts) is an American biochemist and high school teacher. It is T.Z. and Irmgard Chu Distinguished Professor of Chemistry and Professor of Molecular and Cell Biology at the University of California, Berkeley. She is also scientific director since 2006 for the territory biological nanostructures at the Molecular Foundry at the Lawrence Berkeley National Laboratory.

Career

Carolyn Bertozzi is the daughter of the physicist and MIT professor William Bertozzi and his wife Norma. Your grandmother fled in the 1920s from the then fascist Italy to the United States. Carolyn Bertozzi grew up in Lexington ( Massachusetts) and began as an undergraduate at Harvard, first with a biology degree. She then moved to organic chemistry. As part of their senior thesis - comparable to a diploma project - developed Bertozzi a photoacoustic calorimeter. For her doctorate, she transferred to the University of California, Berkeley, where she received her doctorate in 1993 at Mark Bednarski on the subject Synthesis and biological activity of carbon -linked glycosides. As a post - doctoral student Bertozzi worked at the University of California, San Francisco in the field of cell adhesion mediated by oligosaccharides. In 1996 she went back to Berkeley, where she was to 1999 Assistant Professor of Chemistry. From 1999 to 2002 Bertozzi was extraordinary and in 2002 full professor of chemistry and molecular and cell biology at Berkeley. Since 2000 she is also a professor of molecular and cellular pharmacology at the University of California, San Francisco ( UCSF ) and researcher at the Howard Hughes Medical Institute ( Howard Hughes Medical Institute Investigator ).

As up to this point youngest scientist Bertozzi received a 1999 MacArthur Fellowship, the " genius award" in the United States. In 2010 she was awarded the 500,000 U.S. dollars ( not earmarked ) doped Lemelson - MIT Prize as the first woman.

Carolyn Bertozzi has two sisters. One is the mathematician Andrea Bertozzi (* 1965).

Work

The field of Bertozzi mainly comprises the glycans. She developed the first bio-orthogonal reaction. Using this technique it is possible to make specific target structures in living cells and higher organisms, such as mice or zebrafish visible. To this end, they initially used a variant of the Staudinger reaction, the Staudinger ligation. With the Staudinger ligation good marking results can in vivo with cell cultures are obtained, for applications in vivo ( in the living organism ) is the reaction, however, too slow. Therefore Bertozzi developed the copper-free click chemistry, which is based on the discovered by Rolf Huisgen 1,3-dipolar cycloaddition. Bertozzi accelerated azide-alkyne reaction by the use of " biased ", provided with fluorine groups cyclooctyne to several orders of magnitude, so that it proceeds almost quantitatively and bioorthogonal at room temperature within a few minutes without a catalyst. The cuprous catalyst usually used for click chemistry is toxic to cells and organisms. The term coined bioorthogonal Bertozzi for the first time in 2000.

2008 Carolyn Bertozzi co-founded David Rabuka, one of her former students, the company Redwood Bioscience.

Awards and honors

Bertozzi is a member of the National Academy of Sciences (2005), the Institute of Medicine (2011), the American Academy of Arts and Sciences and the German Academy of Sciences Leopoldina ( since 2008).

Publications (selection)

  • PG Wang, CR Bertozzi (ed.): Glycochemistry: principles, synthesis, and applications. Publisher Marcel Dekker, 2001, ISBN 0-8247-0538-6
  • JM Baskin, Bertozzi CR: Copper - free click chemistry. In: J. Lahann (ed.): Click Chemistry for Biotechnology and Materials Science. John Wiley & Sons, 2009, ISBN 0-470-69970-1 limited preview on Google Book Search
  • Sletten EM, Bertozzi CR: From mechanism to mouse: a tale of two bioorthogonal reactions. In: Accounts of chemical research. Volume 44, Number 9, September 2011, pp. 666-676, ISSN 1520-4898. doi: 10.1021/ar200148z. PMID 21,838,330th PMC 3184615 (Free full text ).
  • Sletten EM, Bertozzi CR: A bioorthogonal quadricyclane ligation. In: Journal of the American Chemical Society. Volume 133, Number 44, November 2011, pp. 17570-17573, ISSN 1520-5126. doi: 10.1021/ja2072934. PMID 21,962,173th PMC 3206493 (Free full text ).
  • Bertozzi CR: A decade of bioorthogonal chemistry. In: Accounts of chemical research. Volume 44, Number 9, September 2011, pp. 651-653, ISSN 1520-4898. doi: 10.1021/ar200193f. PMID 21,928,847th
  • K. Godula, ML Umbel, D. Rabuka, Z. Botyanszki, CR Bertozzi, R. Parthasarathy: Control of the molecular orientation of membrane -anchored biomimetic glycopolymers. In: Journal of the American Chemical Society. Volume 131, Number 29, July 2009, pp. 10263-10268, ISSN 1520-5126. doi: 10.1021/ja903114g. PMID 19,580,278th PMC 2716393 (Free full text ).
  • ST Laughlin, JM Baskin, SL Amacher, Bertozzi CR: In vivo imaging of membrane -associated glycans in Developing zebrafish. In: Science. Volume 320, Number 5876, May 2008, pp. 664-667, ISSN 1095-9203. doi: 10.1126/science.1155106. PMID 18,451,302th PMC 2701225 (Free full text ).
  • CW Harland, D. Rabuka, CR Bertozzi, R. Parthasarathy: The Mycobacterium tuberculosis virulence factor trehalose dimycolate imparts desiccation resistance to model mycobacterial membranes. In: Biophysical journal. Volume 94, Number 12, June 2008, pp. 4718-4724, ISSN 1542-0086. doi: 10.1529/biophysj.107.125542. PMID 18,326,657th PMC 2397374 (Free full text ).
  • Prescher JA, Bertozzi CR: Chemistry in living systems. In: Nature Chemical Biology. Volume 1, 2005, pp. 13-21. doi: 10.1038/nchembio0605-13
  • JA Prescher, DH Dube, CR Bertozzi: Chemical remodeling of cell surfaces in living animals. In: Nature. Volume 430, Number 7002, August 2004, pp. 873-877, ISSN 1476-4687. doi: 10.1038/nature02791. PMID 15,318,217th
  • HC Hang, C. Yu, DL Kato, CR Bertozzi: A metabolic labeling approach toward proteomic analysis of mucin -type O- linked glycosylation. In: Proceedings of the National Academy of Sciences of the United States of America. Volume 100, Number 25, December 2003, pp. 14846-14851, ISSN 0027-8424. doi: 10.1073/pnas.2335201100. PMID 14,657,396th PMC 299 823 (Free full text ).
  • KL Kiick, E. Saxon, DA Tirrell, CR Bertozzi: Incorporation of azides into recombinant proteins for chemo- selective modification by the Staudinger ligation. In: Proceedings of the National Academy of Sciences of the United States of America. Volume 99, Number 1, January 2002, pp. 19-24, ISSN 0027-8424. doi: 10.1073/pnas.012583299. PMID 11,752,401th PMC 117 506 (Free full text ).
  • LK Mahal, NW Charter, K. Angata, M. Fukuda, DE Koshland, Bertozzi CR: A small- molecule modulator of poly -alpha 2,8- sialic acid expression on cultured neurons and tumor cells. In: Science. Volume 294, Number 5541, October 2001, pp. 380-381, ISSN 0036-8075. doi: 10.1126/science.1062192. PMID 11,598,302th
  • CR Bertozzi, LL Kiessling: Chemical glycobiology. In: Science. Volume 291, Number 5512, March 2001, pp. 2357-2364, ISSN 0036-8075. PMID 11,269,316th (Review).
  • LK Mahal, KJ Yarema, CR Bertozzi: Engineering chemical reactivity on cell surfaces through oligosaccharide biosynthesis. In: Science. Volume 276, Number 5315, May 1997 pp. 1125-1128, ISSN 0036-8075. PMID 9,173,543th
Biochemistry Lexington (Massachusetts) Fancy mouse Phi Beta Kappa Society American Association for the Advancement of Science Heinrich Wieland Prize Digital Object Identifier Science (journal) Aldrichimica Acta
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