Francesco Guidolin played for Hellas Verona, was then loaned to FC Bologna among others. Overall, however, he returned three times back to Hellas Verona. His career ended in 1986 when AC Venice.
Then he got into coaching. He first coached clubs such as FC Empoli or Atalanta Bergamo. Very successful he worked as manager of Vicenza Calcio 1994-1998. In the 1996/97 season where he won the Italian Cup as a coach, the only title of this club at all. A longer as a coach was also the FC Bologna ( 1999-2003). In these four years Bologna not even dismounted in the B series.
After leaving the FC Bologna, he trained from January 2004 to June 2005 the U.S. Palermo. There he rose in 2004 to Serie A and reached there immediately the UEFA Cup. Then he announced his move to Genoa. The FC Genoa was previously risen to the Serie A. However, the club was doomed to relegation to the third division because of match-fixing and Guidolin finished its work without having a single game denied as a coach. In October 2005, Guidolin eventually became coach of the French first division club AS Monaco. For the 2006/07 season he returned to Italy to Palermo. He was released on 23 April 2007 after a series of eleven games without a win. A few weeks later Palermo brought him back though and Guidolin was able to secure participation in the UEFA Cup. After the season, he resigned from his post. After an engagement of Guidolin at the Queens Park Rangers had smashed for personal reasons, Guidolin took over on 26 November 2007 for the fourth time, the coach of Palermo. On 24 March 2008, he was there again dismissed and replaced by his predecessor Stefan Colantuono.
After the end of his fourth commitment in Palermo, he moved in 2008 to relegated to Serie B Parma. 2009, however, the re-emergence he succeeded with Parma and he managed the club in Serie A 2009/10 in eighth place in the table. 2010 exchange of FC Parma and Udinese Calcio coach. With this exchange Guidolin moved to Udine 2010. After a poor start mitUdinese he reached the end of the 2010/11 season but the fourth place and qualified for the UEFA Champions League. However, Udinese failed to qualify at Arsenal and had the UEFA Europa League. The following season, Udinese reached despite some player sales even the third place and qualify again for the Champions League qualifiers. There they defeated the Portuguese first division side Sporting Braga in a penalty shootout.
- Coppa Italia: 1996/97 with Vicenza Calcio