Samuel J. Danishefsky
Joseph Samuel Danishefsky ( born March 10, 1936 in Bayonne, New Jersey) is an American chemist.
Life and work
Samuel Danishefsky in 1956 made his bachelor's degree in chemistry at Yeshiva University. In 1962 he received his doctorate at Harvard University as a doctor of chemistry. From 1961 to 1963 he was a post - doctoral fellow with Gilbert Stork at Columbia University. Then he moved to the University of Pittsburgh, where he the assistant professor ( 1964-68 ) over an associate professor ( 1968-71 ) and professor ( 1971-79 ) University Professor ( 1978-79 ) worked himself up. 1979 to 1993 he was a professor at Yale University, where he was dean of the chemistry faculty from 1981 to 1987, 1983 to 1989 Eugene Higgins Professor and from 1989 to 1993 was Sterling Professor. Since 1991, Danishefsky director at the Laboratory of Bioorganic Chemistry at Memorial Sloan- Kettering Cancer Center, New York. Since 1993, he has also the Eugene W. Kettering Chair at the Sloan -Kettering Institute for Cancer Research and a Professor of Chemistry at Columbia University held.
Danishefsky deals with the development of new synthetic methods in organic chemistry. It is particularly two directions: First, the synthesis of small, clinically usable molecules to be used for example for the treatment of cancer, Alzheimer's, Huntington's and Parkinson's disease. He begins with natural, biologically active molecules, and manipulated from side branches functional groups in order to obtain materials having higher activity and improved pharmacological properties. The second thrust his research, the synthesis of tumor antigens based on carbohydrates. To this end, he creates complex oligosaccharides, glycoconjugates and glycopeptides.