Anna Marie Duke was born the daughter of John Patrick Duke, a craftsman and a taxi driver, and Frances McMahon, a Kassieriern, in Elmhurst, Queens. Her father was Irish- American and her maternal grandmother, a German. With her brother Raymond, she experienced a tough childhood, because her father was an alcoholic and her mother suffered from depression, so they are often victims of domestic violence. At the age of six years, her mother put her father in front of the door and at the age of eight, she handed over the custody of her to John and Ethel Ross. This recognized her talent, became their manager and forced a career as a child actress.
After a few commercials and small roles Patty Duke got in 1959 her first major role on Broadway in The Miracle Worker, for the filming, she received in 1962 as a 16 -year-old Academy Award for Best Supporting Actress, for which she thanked him with one of the shortest " speeches " she said that is just " Thank you". After Tatum O'Neal and Anna Paquin, it is the third-youngest Oscar winner. She won three Emmys (1977, 1979 and 1980) and two Golden Globe Awards (1963 and 1970). From 1963 to 1966 she had her own television show, The Patty Duke Show. During this time she was also active as a singer and released a music album titled Just Do not Stand There. The title song was in the top 10 on the U.S. charts. From 1985 to 1988 she was chairman of the U.S. Screen Actors Guild.
Patty Duke was married four times, from 1965 to 1969 with director Harry Falk, from June 26 to July 9, 1970 by Michael Tell, from 1972 to 1985 to actor John Astin and since 1986 with Michael Pearce. She has two sons from her third marriage to actor Sean Astin ( born February 25, 1971) and Mackenzie Astin (born 12 May 1973), in 1988 she adopted Kevin.