Janis career started in 1998 with karting, which he did for two years before he went into motor sport 2000. As part of the Swiss championship he drove into the newly launched Formula Lista junior A. With eight wins in twelve races he was superior masters. At the end of this season, he played a round of the French Formula Renault, where he made a further sample of his talent with four championship points. In 2001 he drove for the Italian team Racing DG in Formula Renault 2000 in Italy and in the Eurocup, but was not happy about what compelled him to change to the Swiss team Jenzer Motorsport. Here he was able in 2002 to develop so right and reached the vice - championship. Then he moved with Jenzer 2003 in the Formula Renault V6, where he again vice-European champion.
He remained until 2004 in the Formula Renault V6, however, changed the team DAMS and finished at the end with a lot of bad luck only the fourth final rank. In Dubai, he played on a Lamborghini DAMS also a race of the FIA GT Championship. In 2005, he then went in the GP2 Series for the Spanish team Racing Engineering to the start and was with two wins sixth in the overall standings.
Jani was in 2003 and 2004 Formula 1 test driver for Sauber Petronas. Sponsored by Red Bull, the Swiss played some test runs for his team, Red Bull Racing, RBR short, and was originally intended as a test driver for 2006. After the signing of Robert Doornbos as a test driver for RBR Jani was a test and reserve driver for Red Bull's second Formula 1 team, Scuderia Toro Rosso.
Jani represented in the 2005/06 season including Switzerland in A1GP, won a victory and many more podium finishes that earned the Swiss team the second final rank. Since the F1 test program for 2007 has been reduced drastically and there was no third driver more at GP events from now on, Jani changed at the request of Red Bull in the American Champ Car series. After a season with the Champ Cars he, at that time not exactly known as a favorite team PKV Racing team standing under contract, with three podium finishes completed to the total number 9, he moved back to the A1GP series and brought in the season 2007 / 08 with 4 wins and 11 podium finishes a sensational world title for Switzerland. In the following season, it was only marginally worse; in the end, the team had, after 4 race wins, but be content with the runner-up. In addition, Jani took part in the 24 - hour race at Le Mans in 2009 and was at the end of 12th in the LMP1 class.
Since 2010 Jani drives for the Rebellion Racing team in endurance racing ( up to 2011 Le Mans Series, from 2012 FIA WEC).
On June 24, 2013 Porsche announced Neel Jani included in the circle of his works driver. There he is, Timo Bernhard and Romain Dumas assist in the test work and sit from the 2014 season at the wheel of one of the two new LMP1 cars. Janis multi-year contract with Porsche begins on July 1. In addition to test drive the Porsche sports car experienced pilot in 2013 to complete his planned race program with Rebellion Racing in the American Le Mans Series and in the WEC.