Manuel Poggiali won in 2001 as a 18 -year-old on the Gilera motorcycle world championship in the 125 cc class and 2003 in his rookie season with Aprilia for the world title in the 250 cc class. In the 2004 season, he could not defend his title and was only ninth overall. Poggiali Then changed again in the 125cc class. He finished the 2005 season in tenth place overall. This was followed by the move to KTM and the resurgence in the 250 cc class that season he finished 14th in the overall standings. Thereupon Poggiali decided to a one-year break. In 2008 he went back to the 250 - cc class at the start, but still finished during the season because of disappointing running motivation problems 25 - year his career.
In his 131 starts in the Motorcycle World Championship arrive Manuel Poggiali twelve wins, 35 podiums, eleven pole positions and seven fastest laps.
In the 2013 season, he returned to the Superbike class the Italian motorcycle road championship and riding for the Scuderia Corse team Grandi.