Interstate 81

Major cities

Shuttle and Workarounds

  • Interstate 381 at Bristol
  • Interstate 581 in Roanoke
  • Interstate 481 in Syracuse
Tri-Cities (Tennessee) Interstate 26 Lexington (Virginia) Hagerstown (Maryland) Harrisburg (Pennsylvania) Interstate 380 (Pennsylvania) Clarks Summit, Pennsylvania Greeneville, Tennessee Johnson City (Tennessee) Kingsport (Tennessee) Bristol (Tennessee) Bristol (Virginia) Roanoke (Virginia) Winchester (Virginia) Wilkes-Barre, Pennsylvania Interstate 15 Interstate 16 Interstate 17 Interstate 19 Interstate 25 Interstate 72 Interstate 75 Interstate 76 (Colorado–Nebraska) Interstate 84 (Oregon–Utah) Interstate 86 (Idaho) Interstate 105 (California) Interstate 180 (Illinois) Interstate 180 (Nebraska) Interstate 180 (Pennsylvania) Interstate 180 (Wyoming) Interstate 205 (California) Interstate 205 (Oregon–Washington) Interstate 215 (California) Interstate 235 (Iowa) Interstate 275 (Florida) Interstate 280 (Illinois–Iowa) Interstate 280 (California) Interstate 280 (New Jersey) Interstate 280 (Ohio) Interstate 380 (Iowa) Interstate 380 (California) Interstate 405 (California) Interstate 405 (Oregon) Interstate 480 (Iowa–Nebraska) Interstate 480 (Ohio) Interstate 495 (Massachusetts) Interstate 505 Interstate 580 (California) Interstate 580 (Nevada) Interstate H-1 Interstate H-2 Interstate H-3
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