Wyche Fowler first attended the Davidson College in North Carolina. He then joined the U.S. Army, in their news service he was employed. After leaving the military, he earned his law degree from the Law School of Emory University in Atlanta; after he was from 1965 to 1966 worked as Chief of Staff to Congressman Charles Weltner. He gave up this position and opened a private law firm.
Between 1974 and 1977, Fowler sat in the City Council of Atlanta. This mandate became his springboard to Congress: On April 5, 1977, he won the by-election for the seat, which became vacant by the resignation of Andrew Young. Several confirmations by the voters followed before Fowler in 1986 applied for a seat in the Senate of the United States. He ran against Republican incumbent Mack Mattingly and was successful, and he was able to move in the Senate on January 5, 1987. During his six-year term of office he was considered a liberal on social issues and as moderate in matters of the economy and national security. 1992 Fowler stand for re- election, but was defeated by Republican State Senator Paul Coverdell. Although he won on the first ballot the majority; but this was not absolute because a candidate of the Libertarian Party had recorded a high share of the vote. So it came to a runoff election on 11 November 1992, which decided Coverdell just for themselves.
Under President Bill Clinton Wyche Fowler served between 1996 and 2001 as the United States Ambassador to Saudi Arabia, where he succeeded Ray Mabus. Thereafter, he joined a law firm; he is a member of the governing bodies of several institutions, including the Carter Center at Emory University. He was also Chairman of the Middle East Institute, based in Washington.