Jesse Slocumb (* 1780 in Spring Bank, Wayne County, North Carolina, † December 20, 1820 in Washington DC ) was an American politician. Between 1817 and 1820 he represented the state of North Carolina in the U.S. House of Representatives.
Jesse Slocumb attended the schools of his home and worked afterwards in agriculture as a planter. He also held various local offices. Between 1802 and 1808, he was an official land register ( Register of Deeds ) in his home district. Politically, Slocumb member of the Federalist Party, founded by Alexander Hamilton.
In the congressional elections of 1816, he was elected in the fourth constituency of North Carolina in the U.S. House of Representatives in Washington, where he became the successor of William J. Gaston on March 4, 1817. After a re-election, he could remain until his death on December 20, 1820 in Congress. He died of pleurisy, which he had contracted on a trip back to the capital.