James Gillespie (c. 1747 in Kenansville, Duplin County, North Carolina; † January 11, 1805 in Washington DC ) was an American politician. Between 1793 and 1805 he represented twice the state of North Carolina in the U.S. House of Representatives.
James Gillespie received a good education and later took as a member of the militia of North Carolina at independence war part. In 1776 he was a member of the Constituent Assembly of North Carolina. From 1779 to 1783 he was a member of the House of Representatives from North Carolina; 1784-1786 he was a member of the State Senate. Politically Gillespie was an opponent of the federal government under President George Washington ( Anti- Administration). Later he became a member of, founded by Thomas Jefferson Democratic- Republican Party.
In the congressional elections of 1792 Gillespie was selected in the fifth constituency of North Carolina in the U.S. House of Representatives, where he became the successor of Nathaniel Macon on March 4, 1793. After two re- election he was able to complete in Congress until March 3, 1799 three legislative periods. In 1795, the Eleventh Amendment was adopted. In the elections of 1802 Gillespie was re-elected in the fourth district in the Congress, which had moved from Philadelphia to Washington. He could exercise his office until his death on 11 January 1805.