Argentin was in the 1978 and 1979 rookies in the Italian national railway. In addition, he passed the high school and trained as a dentist. Age of 19 was Argentin in 1980 with a contract with the Italian cycling team Benotto professional drivers.
Argentin was with 86 wins as one of the best cyclists of the 1980s. His greatest successes came in one-day classics. In 1986, he was road cycling championships, an achievement that he almost repeated a year later, when he was vice-champion. These victories fall within the period of its most successful period between 1985 and 1987, he won three times in succession the classic Liege -Bastogne- Liege.
For large tours he was less successful than sprint specialist, but won during his career thirteen stages at the Giro d' Italia and two stages at the Tour de France. At the Giro came Argentin 1981-1994 nine times in the final scoring and had 1984 third place his best finish. At the Giro in 1993, in which he won two stages, he ordered ten legs the pink jersey of the overall leader. 1988, 1990 and 1991 he boycotted in a dispute with the Italian press the Giro. Three final rankings between 1990 and 1992 by the Tour de France to Beech, the 27th place in 1990 was the best result. In addition to its World Cup title came Argentin 1982-1988 seven times in the ranks. 1985 ( 3 ) 1986 ( 1 ) and 1987 ( 2 ) he stood on the podium in each case. Although he played seven times the race Milan - Sanremo, he could never win the main Italian spring classic. In 1982 he was third in 1992 and second, after the seemingly secure and pre-announced victory in the final sprint, he was removed from the open-minded on the descent of the Poggio di Sanremo Irishman Sean Kelly.
In June 1994, Argentin declared surprising and without giving any reason for his resignation. In the late 1980s he had moved his residence to Monaco. He was part owner of a large sawmill and a construction company for social housing.